Frequently Asked Questions
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Most Asked
About the Protocol
NADPure is an at-home NAD+ cellular protocol. Each shipment contains pre-filled longevity pens loaded with clinically pure NAD+ in sterile saline solution. You apply the dose directly beneath the skin (into the fatty tissue of your abdomen) following the included protocol guide. It takes under 60 seconds.
Two ingredients: NAD+ (nicotinamide adenine dinucleotide) in its oxidised form, and sterile saline solution (sodium chloride 0.9%) as the carrier. No fillers, no binders, no proprietary blends. Every batch comes with an independent Certificate of Analysis.
Oral NAD+ precursors (NMN, NR) are broken down in the gut and metabolised in the liver before reaching your bloodstream. Research in Cell Metabolism (Liu et al., 2018) showed oral NR converts to nicotinamide before reaching peripheral tissues. Beneath-the-skin delivery bypasses gut degradation entirely and delivers NAD+ directly into systemic circulation.
IV NAD+ drips deliver the molecule intravenously, which bypasses the gut. However, they require 2–6 hours in a clinic, cost €500–€1,500 per session, and most users describe the effects as transient — lasting days, not weeks. NADPure delivers NAD+ directly beneath the skin at home in under 60 seconds, on a sustained protocol designed for ongoing maintenance.
NADPure is available as a one-time purchase or a subscription. We recommend the subscription because NAD+ levels return to baseline within 2–4 weeks of stopping — this is a maintenance protocol, not a one-time fix. You can cancel, pause, or adjust frequency anytime.
Because it is one. A supplement is something you swallow and hope absorbs. A protocol involves precise dosing, a specific delivery method, circadian timing guidance, and systematic ongoing maintenance. The delivery format, the lab verification, and the timing recommendations are all part of the protocol — not just the molecule.
Using the Pen
Clean the application site (abdomen) with the included alcohol swab. Press the pre-filled pen against your skin. Click. Hold for 5 seconds. Cap the pen and dispose safely. Total time: under 60 seconds. A detailed first-time guide and video walkthrough are included with every shipment.
Most users describe a brief pinch — less uncomfortable than a blood draw. Some feel mild warmth at the site for a few minutes. Bruising is uncommon with proper site rotation. By the second or third application, most people barely notice.
Into the tissue layer of the abdomen — the same site used for at-home wellness pen use worldwide. Your shipment includes an application site rotation guide to ensure you alternate locations properly.
NAD+ follows a circadian rhythm, fluctuating up to 53% across a 24-hour period. Our protocol includes timing guidance based on published research. Most users apply in the morning. The timing protocol card is included in every shipment.
The standard protocol frequency is included with your shipment and depends on your chosen plan. Consistency matters more than frequency — a sustained, regular protocol outperforms sporadic high doses.
Continue with your next scheduled dose. Do not double up. NAD+ maintenance is cumulative — one missed dose will not reset your progress.
Yes. A full 45-second demonstration video is available on our How It Works page and is linked in the guide included with your shipment.
Results & Expectations
Individual responses vary. The most common early signal is the absence of the usual afternoon energy crash, typically within the first week. Sleep improvements often follow in week two. Cognitive clarity and physical recovery changes are most commonly reported in weeks three and four.
Many people feel nothing dramatic in the first few days — and that is normal. NAD+ rebuilds at the cellular level before producing noticeable effects. The most common first sign is a subtle steadiness in energy: no crash, no surge, just even. Some users report improved afternoon focus by day 4–7.
No. NAD+ levels return to pre-supplementation baseline within 2–4 weeks of stopping, across all delivery formats (oral, IV, beneath-the-skin). This is why NADPure is structured as an ongoing maintenance protocol, not a one-time treatment.
Your NAD+ levels will gradually return to where they were before you started. Most users who pause and restart report noticing the difference clearly — the return of the afternoon crash, disrupted sleep, or cognitive fog is often more noticeable than the original improvement.
NAD+ is a molecule your body already produces. It is generally compatible with other supplements. If you are on current medications, consult your doctor before starting. We do not recommend combining with high-dose flushing niacin.
We cannot guarantee individual results. What we can tell you is that NAD+ decline after 40 is universal and well-documented, and beneath-the-skin delivery bypasses the primary barriers that make oral supplementation unreliable. Our 30-day guarantee means you can try the full protocol with no financial risk.
Quality & Safety
NADPure is produced in an EU-certified production facility under strict quality control protocols.
Yes. Every batch undergoes independent third-party laboratory testing for purity, sterility, heavy metals, and endotoxins. An independent purity certificate with batch number and test results is included with every shipment.
A purity certificate (also called a Certificate of Analysis) is a document from an independent laboratory that verifies the purity, potency, and safety of a specific product batch. It includes the batch number, purity percentage, sterility confirmation, heavy metal screening, and endotoxin testing results. We include one with every shipment so you never have to take our word for it.
NADPure complies with all applicable EU regulations for product safety, labelling, and shipping. Country-specific regulatory information is available on our shipping page.
You may have seen a 2022 preclinical study suggesting NR (nicotinamide riboside) may promote breast cancer metastasis in a specific mouse model. This study used a specific oral NR supplement at high doses in a specific cancer model. It is a preclinical finding, not a clinical one, and has not been replicated in human studies. NADPure delivers NAD+ directly — not NR — which is a different molecule with a different metabolic pathway. We believe in addressing these concerns openly rather than pretending they do not exist. If you have a personal or family history of cancer, consult your physician before starting any new protocol.
The most commonly reported side effects are mild and transient: brief discomfort at the application site, mild warmth or flushing, and occasional bruising. These typically resolve within minutes. Serious adverse effects have not been reported in our customer base. If you experience anything unusual, discontinue use and contact your doctor.
We do not recommend NADPure during pregnancy or breastfeeding. There is insufficient research on exogenous NAD+ supplementation in these populations. Consult your physician.
Orders & Shipping
Cold-chain. NADPure is shipped in insulated packaging that maintains 2–8°C from our facility to your door. This preserves the molecular integrity of the NAD+ throughout transit.
We currently ship to Germany, the Netherlands, Sweden, Austria, Denmark, and France, with more EU countries being added. Check our shipping page for the most current list.
Standard delivery is 3–5 business days within the EU. Tracking is provided for every order.
We offer a 30-day money-back guarantee. Try the full protocol for 30 days. Follow the dosing and timing guidance. If you do not notice a meaningful difference, contact support@trynadpure.com and we will refund your purchase in full. No complicated process. No interrogation.
Through your account dashboard or by emailing support@trynadpure.com. No minimum commitment. Cancel, pause, or adjust frequency anytime.
Email support@trynadpure.com. We respond within 24 hours. We answer honestly — including telling you if NADPure might not be the right fit for your situation.
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